There are an estimated 195,941 dentists in the U.S., and approximately 154,000 practices. The cost of opening a dental clinic is about $1 million, and recent data shows that the cost of running a practice is approximately 60% to 80% of total annual revenues. If you are running a dental practice, standing out from the crowd can be difficult, and running an efficient practice is important in staying afloat. Marketing your practice to an online audience can help you gain more clients, but you would first need to set up a dental website.